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The dominant pigment is cyanidin-3-glucoside, abbreviated C3G, the most abundant anthocyanin in purple corn and one of the most studied in vascular research. In cell studies, C3G directly upregulates endothelial nitric oxide synthase, the enzyme responsible for producing nitric oxide inside blood vessel walls.
Nitric oxide is what keeps arteries flexible and responsive to changes in blood flow. After menopause, declining estrogen reduces the body's production of nitric oxide, and this loss of vascular flexibility is one of the established reasons cardiovascular risk rises sharply in women during their fifties.
A meta-analysis of 65 randomized controlled trials, published in The American Journal of Clinical Nutrition, found that anthocyanin-rich foods and extracts consistently improved flow-mediated dilation, a direct clinical measure of how well arteries relax and widen. In the subanalysis by anthocyanin type, cyanidin, the one dominant in purple corn, showed a meaningful effect.
One small pilot study tested purple corn extract directly in Peruvian adults with untreated mild to moderate hypertension. At 300 milligrams of anthocyanin daily for three weeks, both systolic and diastolic blood pressure dropped, though the study was preliminary and not large enough to be conclusive on its own.
The traditional addition of lime juice at the end is not incidental. Anthocyanins are most stable below a pH of about 4, and the acid from the lime slows their degradation in the liquid, which is part of why traditional chicha morada holds both its color and its anthocyanin content for days under refrigeration.
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